ea0041gp149 | Pituitary - Clinical | ECE2016
Ritvonen Elina
, Pitkanen Esa
, Karppinen Atte
, Vehkavaara Satu
, Demir Hande
, Paetau Anders
, Schalin-Jantti Camilla
, Karhu Auli
Introduction: In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumour features and reduced response to somatostatin analogue treatment. AIP is a regulator of Gαi signaling, but it is not known how the biological function of the Gαi pathway is controlled.Aim: To study somatic GNAS and AIP mutation status, AIP and Gαi-2 protein expressions, Ki67 proliferation indices, and clinical parameters in p...